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After its completion, fat excretion is slower and does not affect weight loss. Prevents the digestion of up to one-third of the fat you consume. • Helps you learn how to count calories. Does Orlistat Work For Weight Loss? Orlistat is effective in preventing fat absorption from your diet which will help reduce you total calorie intake. I weigh 194lbs but my target is 165lbs. It is the branded version of Orlistat, which functions similarly but is less expensive. • It gives you a feeling of well. Once you’re down at least 20 pounds, people will notice. Now, if you want others to see your results, you’re likely going to have to drop a size or two, first. I'm too scared to weigh myself as of yet as I will be sooo disappointed if i haven't lost anything but I do feel my trousers are a little looser around the waist. 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